Genomics Examining the expression of genes in immune cells and mitochondrial genomes. Metabolism Probing the utilization of mitochondrial oxidative phosphorylation vs. glycolysis in immune cells and accumulation of metabolites in plasma. Microbiome Comparing gut microbiota, including bacteria, eukaryotes, and viruses in ME/CFS patients and controls. Physiology Observing the effect of an exercise challenge on physiology and function. Brain Function Using state-of-the-art brain imaging to study oxidative stress in ME/CFS.