Recruitment Update at Los Angeles Site

CPET demonstration

Now recruiting in the Los Angeles area:  People with ME/CFS and healthy, inactive control participants for the NIH-funded Cornell University Collaborative Research Center study of ME/CFS.  If accepted into the study, participants will complete two cardiopulmonary exercise tests over two days with blood drawn before and after each test, and wear a wrist watch device to measure physical activity for 10 days before and 10 days after the exercise tests.  Exercise testing will be completed at the ID Med clinic in Torrance, CA.  For more information and/or to be screened for acceptance into the study, please contact:

Jared Stevens
jared@workwellfoundation.org
209-599-7194

Inaugural Harvard ME/CFS Collaboration Symposium

Symposium participants

Dr. Maureen Hanson participated in the Inaugural Harvard Science Symposium sponsored by the Open Medicine Foundation that was held in Boston, MA on June 6-7, 2019. On June 6 she presented a talk on ongoing research in the NIH-funded Cornell ME/CFS U54 Center. She also presented on June 7 at the public symposium held in a theater in nearby Somerville, MA. The talks from the public symposium have been made available by OMF. Dr. Hanson’s talk is below and the full list of talks can be found here.

Immune dysregulation in ME/CFS

InvestinME Research Events

Richard Simpson, event organizing, from InvestinME

InvestinME Research hosted a series of events in London with the purpose of promoting better education about ME/CFS and increasing international collaboration on ME/CFS research. The series began with the Thinking the Future Young/ECR conference on May 28th, 2019, for which Hanson lab graduate student Alexandra Mandarano received a travel scholarship to attend. Dr. Maureen Hanson attended and presented at the ninth Biomedical Research into ME Colloquium and at the public 14th Invest in ME Research Conference on May 31st.

UPDATE: Presentations and the conference report from the 14th Invest in ME Research International ME Conference are now available. Dr. Maureen Hanson‘s talk is among those uploaded and is included below. The full report is available on the InvestinME website here.

ISEV Annual Meeting 2019

Ludovic Giloteaux, Ph.D.

The International Society for Extracellular Vesicles (ISEV) held their 2019 annual meeting in Kyoto, Japan from April 24th to 28th. Center member Dr. Ludovic Giloteaux attended the conference to network with international experts on the latest extracellular vesicle (EV) research. Dr. Giloteaux also presented some of our current EV research on cytokine and miRNA profiling of plasma EVs in ME/CFS. Check out the conference program for an overview of what information was covered.

Exertion intolerance: What is the evidence telling us?

Betsy Keller, Ph.D.

Clinical core co-director Dr. Betsy Keller presented on the second day of the NIH Accelerating Research on ME/CFS meeting. Dr. Keller outlined exertion intolerance in ME/CFS drawing upon her years of experience in the field. Her talk includes some preliminary data being generated from our NIH-funded Center. Dr. Keller’s complete talk can be viewed below.

Cellular Metabolism of Immune Cells

Alexandra Mandarano

At the NIH Accelerating Research on ME/CFS meeting, Alexandra Mandarano, a Ph.D. candidate in Dr. Hanson’s lab, presented “Cellular Metabolism of Immune Cells”. The talk outlines a study that was performed in collaboration with Simmaron Research and focused on immunometabolism in people with ME/CFS as well as in healthy controls. To elaborate further, Alexandra Mandarano with the help of Jessica Maya, a graduate student in Dr. Hanson’s lab, performed Seahorse bioenergetics assays along with other experiments to better understand the metabolic fitness of immune cells from this population. Please see the video below to watch the full talk.

Mitochondrial DNA Mutation and Disease

Zhenglong Gu, Ph.D.

Center member Zhenglong Gu, PhD, presented on mitochondrial DNA mutation and disease at Cornell University on April 19, 2019. Dr. Gu is participating in the ENID Center to examine the role of mitochondrial genomes in ME/CFS.

“Next Steps for ME/CFS Research”

Dr. Maureen Hanson

Dr. Maureen Hanson spoke on the “Next Steps for ME/CFS Research” panel at the NIH meeting “Accelerating Research on ME/CFS” on April 5, 2019.  The text of her statement and some by Dr. Jose Montoya on the same panel can be found here.  A transcript of the prior remarks at the meeting by Dr. Francis Collins is available here.

Review Concerning Chronotropic Intolerence in ME/CFS

Our collaborators at Workwell Foundation have published a review concerning chronotropic incompetence in ME/CFS patients. What this means is that studies that have ME/CFS subjects exercise to a percentage of their maximal heart rate may be actually having the subject exercise at their maximum capacity, since their actual heart rate may often be lower than expected. Please see the link below to be directed to the publication.

https://www.frontiersin.org/articles/10.3389/fped.2019.00082

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