Upcoming InvestinME Research Events

InvestinME Research has put together a series of events in London with the purpose of promoting better education about ME/CFS and increasing international collaboration on ME/CFS research. The series begins with the Thinking the Future Young/ECR conference on May 28th, 2019, for which Hanson lab graduate student Alexandra Mandarano has received a travel scholarship to attend. Dr. Maureen Hanson will be attending and presenting at the ninth Biomedical Research into ME Colloquium and at the public 14th Invest in ME Research Conference on May 31st.

ISEV Annual Meeting 2019

Ludovic Giloteaux, Ph.D.

The International Society for Extracellular Vesicles (ISEV) held their 2019 annual meeting in Kyoto, Japan from April 24th to 28th. Center member Dr. Ludovic Giloteaux attended the conference to network with international experts on the latest extracellular vesicle (EV) research. Dr. Giloteaux also presented some of our current EV research on cytokine and miRNA profiling of plasma EVs in ME/CFS. Check out the conference program for an overview of what information was covered.

Exertion intolerance: What is the evidence telling us?

Betsy Keller, Ph.D.

Clinical core co-director Dr. Betsy Keller presented on the second day of the NIH Accelerating Research on ME/CFS meeting. Dr. Keller outlined exertion intolerance in ME/CFS drawing upon her years of experience in the field. Her talk includes some preliminary data being generated from our NIH-funded Center. Dr. Keller’s complete talk can be viewed below.

Cellular Metabolism of Immune Cells

Alexandra Mandarano

At the NIH Accelerating Research on ME/CFS meeting, Alexandra Mandarano, a Ph.D. candidate in Dr. Hanson’s lab, presented “Cellular Metabolism of Immune Cells”. The talk outlines a study that was performed in collaboration with Simmaron Research and focused on immunometabolism in people with ME/CFS as well as in healthy controls. To elaborate further, Alexandra Mandarano with the help of Jessica Maya, a graduate student in Dr. Hanson’s lab, performed Seahorse bioenergetics assays along with other experiments to better understand the metabolic fitness of immune cells from this population. Please see the video below to watch the full talk.

Mitochondrial DNA Mutation and Disease

Zhenglong Gu, Ph.D.

Center member Zhenglong Gu, PhD, presented on mitochondrial DNA mutation and disease at Cornell University on April 19, 2019. Dr. Gu is participating in the ENID Center to examine the role of mitochondrial genomes in ME/CFS.

“Next Steps for ME/CFS Research”

Dr. Maureen Hanson

Dr. Maureen Hanson spoke on the “Next Steps for ME/CFS Research” panel at the NIH meeting “Accelerating Research on ME/CFS” on April 5, 2019.  The text of her statement and some by Dr. Jose Montoya on the same panel can be found here.  A transcript of the prior remarks at the meeting by Dr. Francis Collins is available here.

Review Concerning Chronotropic Intolerence in ME/CFS

Our collaborators at Workwell Foundation have published a review concerning chronotropic incompetence in ME/CFS patients. What this means is that studies that have ME/CFS subjects exercise to a percentage of their maximal heart rate may be actually having the subject exercise at their maximum capacity, since their actual heart rate may often be lower than expected. Please see the link below to be directed to the publication.

https://www.frontiersin.org/articles/10.3389/fped.2019.00082

Outreach in Japan

Image Credit: admissions.oist.jp

This past November, @DrMaureenHanson visited the Okinawa Institute of Science and Technology Graduate University in Japan to participate in their distinguished speaker series. Dr. Hanson’s talk provided general awareness about ME/CFS and shared details on the Center’s research. In particular, the research topics covered were the functioning of immune cells, cellular metabolism, the microbiome, neuroimaging, and exercise physiology.  While in Japan, Dr. Hanson spoke with a representative of the Japan ME Association.  ME/CFS researchers in Japan hope to attend the April 2019 NIH meeting.

New Center Manager

Let us welcome Carl Franconi to the Cornell ME/CFS Collaborative Research Center team. He will be joining us as the Manager for the Center for Enervating NeuroImmune Disease. Carl will be taking over the administrative workload from Ms. Susi Varvayanis, who has recently taken a full-time position in the Graduate School to pursue her interest in supporting PhDs interested in non-academic careers, a role she had been carrying out part-time while efficiently managing our NIH ME/CFS CRC.

Continue reading “New Center Manager”

New metabolomics study published in Metabolites

Arnaud Germain, Ph.D.

The Hanson lab, which is a member of our Center, has recently published a metabolomics study in the journal Metabolites. Visit https://www.facebook.com/CornellMECFSCenter/ for a summary of the article. The complete publication can be accessed using the link below.

https://www.mdpi.com/2218-1989/8/4/90/htm

Arnaud Germain, David Ruppert, Susan M. Levine, and Maureen R. Hanson. 2018.  Prospective Biomarkers from Plasma Metabolomics of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome Implicate Redox Imbalance in Disease Symptomatology. Metabolites 8(4), 90

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