Members of the Cornell ME/CFS Center joined advocacy representatives, Columbia Center for Solutions, JAX ME/CFS Center, NIH, and RTI for the Second Annual ME/CFS Consortium meeting. The group met in New York City on October 22 and 23, 2019 to discuss current research progress and future collaborative efforts.
A generous donor has offered to match up to $25,000 in donations to the Cornell Center for Enervating Neuroimmune Disease for our work on immune dysregulation in ME/CFS, which was recently described in Dr. Maureen Hanson’s talk at the Stanford OMF Community Symposium.
Please visit our donation page if you wish to support our work on the immune system in ME/CFS. All donations are gratefully received.
The Third Annual Community Symposium on the Molecular Basis of ME/CFS followed the Open Medicine Foundation working group meeting at Stanford University on September 7th, 2019. Keynote speaker, Dr. Maureen Hanson, started her talk discussing data on metabolomics, immune cells, extracellular vesicles, and RNA gene expression. The second portion of her talk went into her thoughts on the disease. OMF has uploaded her talk to YouTube, which can be found here.
The Open Medicine Foundation held their third annual collaborative team meeting on ME/CFS. Dr. Maureen Hanson joined approximately 60 other researchers at Standford University from September 4th to 6th, 2019 to discuss their latest unpublished and preliminary data on the disease. A diverse field of scientific topics were discussed as noted in the agenda.
Our collaborators at the Workwell Foundation, working with physical therapists and exercise physiologists, have published a case report in the Cardiopulmonary Physical Therapy Journal on measurement reproducibility over the two days of a two-day cardiopulmonary exercise test (CPET). The report looked at the variability of CPET results from six people with and without medical diagnoses of fatiguing illnesses. All of the participants were women and matched by age and BMI. Although the authors point out that generalizations are not possible due to the low number of included subjects, the response to exercise by both individuals with ME/CFS is important to highlight. Some of these observations have been summarized below.
- Measurements at ventilatory anaerobic threshold (VAT), the level at which a person can generally work for an extended amount of time, were considerably decreased on CPET day two. Therefore, time spent above VAT will cause fatigue and require rest—demonstrating the importance of activity pacing strategies to manage physical demands.
- Early onset of VAT in both individuals with ME/CFS may indicate a diminished metabolic capacity to perform usual tasks.
- CPET day two measurements at VAT for the low-functioning participant with ME/CFS suggests activities more intense than slow walking or standing while washing dishes could trigger activation of an impaired oxidative metabolic pathway that could prompt postexertional symptoms.
- Day-to-day variability in VAT could lead to difficulty in estimating the metabolic costs of activities. However, variations in functional capacity could be used to form the basis for scheduling activities as part of a pacing self-management program.
- A two-day CPET could be a useful diagnostic tool in identifying postexertional malaise.
Now recruiting in the Los Angeles area: People with ME/CFS and healthy, inactive control participants for the NIH-funded Cornell University Collaborative Research Center study of ME/CFS. If accepted into the study, participants will complete two cardiopulmonary exercise tests over two days with blood drawn before and after each test, and wear a wrist watch device to measure physical activity for 10 days before and 10 days after the exercise tests. Exercise testing will be completed at the ID Med clinic in Torrance, CA. For more information and/or to be screened for acceptance into the study, please contact:
Our collaborators at the Workwell Foundation have put together a two-part continuing education course on ME/CFS developed for PTs, OTs, nurses, and ATCs. Part 1 covers the introduction and identification of ME/CFS and Part 2 goes into etiology and analeptic management. The content is available through MedBridge.
Dr. Maureen Hanson participated in the Inaugural Harvard Science Symposium sponsored by the Open Medicine Foundation that was held in Boston, MA on June 6-7, 2019. On June 6 she presented a talk on ongoing research in the NIH-funded Cornell ME/CFS U54 Center. She also presented on June 7 at the public symposium held in a theater in nearby Somerville, MA. The talks from the public symposium have been made available by OMF. Dr. Hanson’s talk is below and the full list of talks can be found here.
InvestinME Research hosted a series of events in London with the purpose of promoting better education about ME/CFS and increasing international collaboration on ME/CFS research. The series began with the Thinking the Future Young/ECR conference on May 28th, 2019, for which Hanson lab graduate student Alexandra Mandarano received a travel scholarship to attend. Dr. Maureen Hanson attended and presented at the ninth Biomedical Research into ME Colloquium and at the public 14th Invest in ME Research Conference on May 31st.
UPDATE: Presentations and the conference report from the 14th Invest in ME Research International ME Conference are now available. Dr. Maureen Hanson‘s talk is among those uploaded and is included below. The full report is available on the InvestinME website here.
The International Society for Extracellular Vesicles (ISEV) held their 2019 annual meeting in Kyoto, Japan from April 24th to 28th. Center member Dr. Ludovic Giloteaux attended the conference to network with international experts on the latest extracellular vesicle (EV) research. Dr. Giloteaux also presented some of our current EV research on cytokine and miRNA profiling of plasma EVs in ME/CFS. Check out the conference program for an overview of what information was covered.