Published on August 12, 2021, Maureen Hanson wrote an editorial in Frontiers Science News that highlights the enterovirus theory of ME/CFS. Particularly, Hanson emphasizes that, “ME/CFS is neither a rare nor a trivial illness.” She provides insight into the potential link between ME/CFS and a chronic EV infection. This probable link was reviewed in detail in a Frontiers in Medicine June 2021 article by Adam O’Neal and Hanson. Hanson discusses the possibility that SARS viruses may be the second class of RNA viruses to cause a chronic illness, given the existence of “long COVID.”
This methodologically focused review covers aspects of ME/CFS pathophysiology that are consistent with chronic enterovirus infection outcomes and then closely examines the technology used in in past ME/CFS publications to determine how rigorously the enterovirus theory of disease etiology has been investigated.
For the ME International Awareness Day, Director Maureen Hanson is providing a Pecha Kucha on ME/CFS. This is a short video presentation in which 20 slides are presented, automatically changing every 20 seconds. This format has been developed to convey information quickly in a visual manner (see https://www.pechakucha.com/ for more information).
Jessica Maya, a graduate student in the Genetics, Genomics, and Development Program at Cornell University in Maureen Hanson’s lab, talks about ME/CFS, the immune system response, and the fuels that energize immune cells to properly defend the body. This talk was adapted from Cornell University’s 3 Minute Thesis Finalists Round Competition, where she was tasked to explain her thesis work in under 3 minutes in an engaging form that could be understood by an intelligent audience with no background in the research area.
We are proud to announce our latest plasma proteomics publication is available as open access in Proteomes.
This manuscript takes a look at 4,790 circulating plasma proteins from 20 ME/CFS women compared to 20 healthy women, over an unprecedented range, for ME/CFS, of 9 orders of magnitude.
Pathway analysis uncovered disrupted cell-to-cell communication, specifically in the ephrin-Eph signaling pathway. This pathway is crucial for many aspects of our body’s homeostasis, including development, physiology, and disease regulation.
Additionally, the paper outlines promising results for the development of a diagnostic test using protein ratios.
First author, Arnaud Germain, PhD, outlines these findings in a video abstract below.
Chinese, French, and Spanish subtitles for the video abstract are available. See video settings to select an option.
Our MECFSnet collaborator, RTI, which operates the Data Management and Coordinating Center (DMCC) for the NIH ME/CFS Centers, has officially launched two research tools – mapMECFS and searchMECFS.
With mapMECFS, the Cornell ME/CFS Collaborative Research Center has worked promptly to submit data to the network. A total of 8 datasets are available. Below lists the publications from which the datasets have been uploaded.
- Germain, A.; Levine, S.M.; Hanson, M.R. In-Depth Analysis of the Plasma Proteome in ME/CFS Exposes Disrupted Ephrin-Eph and Immune System Signaling. Proteomes 2021, 9, 6. (Fully and partially normalized uploaded separately)
- Germain, A.; Barupal, D.K.; Levine, S.M.; Hanson, M.R. Comprehensive Circulatory Metabolomics in ME/CFS Reveals Disrupted Metabolism of Acyl Lipids and Steroids. Metabolites 2020, 10, 34. (Global metabolites and Lipidomics uploaded separately)
- Mandarano AH, Giloteaux L, Keller BA, Levine SM, Hanson MR. 2018. Eukaryotes in the gut microbiota in myalgic encephalomyelitis/chronic fatigue syndrome. PeerJ 6:e4282
- Billing-Ross, P., Germain, A., Ye, K. et al. Mitochondrial DNA variants correlate with symptoms in myalgic encephalomyelitis/chronic fatigue syndrome. J Transl Med 14, 19 (2016).
- Germain A, Ruppert D, Levine SM, Hanson MR. Metabolic profiling of a myalgic encephalomyelitis/chronic fatigue syndrome discovery cohort reveals disturbances in fatty acid and lipid metabolism. Mol Biosyst. 2017 Jan 31;13(2):371-379.
- Giloteaux, L., Goodrich, J.K., Walters, W.A. et al. Reduced diversity and altered composition of the gut microbiome in individuals with myalgic encephalomyelitis/chronic fatigue syndrome. Microbiome 4, 30 (2016).
Read more to see the full announcement from RTI.
On September 23, 2020, a CDC ME/CFS Stakeholder Engagement and Communication (SEC) call took place, featuring a presentation by Dr. Maureen Hanson, ENID Center Director, on “Immune Dysfunction in ME/CFS”. Dr. Elizabeth Unger, Branch Chief of CDC’s Chronic Viral Diseases Branch, provided CDC programmatic updates. The SEC call transcript, audio, and presentation slides are now available on the CDC’s website. Direct links to specific content, including Hanson’s slideshow presentation, are below.
Listen to the audio recording.
Read the transcript.
View Dr. Hanson’s presentation.
On November 4-5, 2020, Cornell University and Weill Cornell Medicine held a COVID-19 Summit to exchange information about research into the disease ongoing at both institutions. Dr. Maureen Hanson presented a “flash” talk with three slides to introduce Cornell COVID-19 researchers to the similarity between long-haul COVID-19 and ME/CFS. Content from Hanson’s talk is below.
At the Swedish RME annual ME/CFS conference on Oct. 14, 2020, Clinical Core Co-Director, Dr. Betsy Keller, presented virtually on post-exertional malaise (PEM). Keller goes into detail on PEM by covering what it is, ways to assess impairment due to PEM, and strategies to minimize PEM. Her full talk “PEM: Strategies for determining and managing the cardinal symptom of ME/CFS” can be viewed below and is also available on YouTube here.
For an English version of Swedish RME’s website visit this link.
Center investigator Dr. Ludovic Giloteaux is lead author of a new publication out in the Journal of Translational Medicine. The paper describes cytokine profiling in extracellular vesicles (EVs) in ME/CFS. The study specifically looks at EVs from the plasma of 70 participants, 35 of which are diagnosed with ME/CFS and compared with 35 healthy controls. Both female and male participants were included in this work. Dr. Jesus Castro-Marrero visited our lab from Spain on a fellowship to contribute to the project.
One key finding of the study is the noted disturbances in cytokine networks.. Disturbances in these cytokine networks were seen in both plasma and EVs, and provides further evidence of immune dysregulation in ME/CFS. We are using information from this work to inform our further studies on EVs from blood collected before and after an exercise challenge. Stay tuned for future publications from our Center on this topic.