Altered T cell metabolism and dysregulated cytokine associations in ME/CFS

The ENID Center is excited to announce a new publication in the Journal of Clinical Investigation. Recent Hanson Lab graduate, Dr. Alexandra Mandarano, is the lead author of “Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations”. This paper goes into our research exploring the immune system in people with ME/CFS.

UPDATE: The final publication of the paper was released on February 10, 2020. Accompanying this release, Dr. Mady Hornig wrote a related commentary: “Can the light of immunometabolism cut through “brain fog”?“.

Dr. Daniel Peterson and Simmaron Research staff Dr. Gunnar Gottschalk and Marco Maynard provided blood samples from carefully diagnosed ME/CFS cases and controls that were critical for carrying out the study.  Thanks to Simmaron Research and a private donor, as well as NIH, for financial support for the study.  A press release was issued by NIH.

Furthermore, we have launched a new initiative to help expand the reach of our research. Dr. Mandarano has recorded a talk that walks you through this publication. The video is hosted on our new YouTube channel. Check out this video below and stay tuned for future posts and videos about our research.

Betsy Keller speaks in Norway November 2019

As part of the Norwegian ME Association’s Knowledge Campaign 2019, Dr. Betsy Keller traveled to Norway to present on post-exertional malaise. The Norwegian ME Association has uploaded her talk to YouTube and can be watched using the embedded video below. Additionally, the following links will direct you to associated information translated to English via Google Translate.

Norwegian ME Association’s Knowledge Campaign 2019

Post about Dr. Keller’s talk including information on PEM management

 

ENID Center featured in Norwegian blog

Quote translation: “… how ME became the most contentious disease of our time”
Photo: De Bortgjemte (The Hidden)

A Norwegian blog, The Hidden, published a summary of our NIH funded research center efforts.  The blog is by physical therapist and journalist Jørgen Jelstad. He covers various aspects relating to ME/CFS and has also reviewed the other two NIH funded research centers—Columbia’s Center for Solutions for ME/CFS and The Jackson Laboratory’s Collaborative Research Center. For an English translation of the website by Google Translate iTool, please visit this link.

Second annual ME/CFS Consortium meeting

Members of the Cornell ME/CFS Center joined advocacy representatives, Columbia Center for Solutions, JAX ME/CFS Center, NIH, and RTI for the second annual ME/CFS Consortium meeting. The group met in New York City on October 22 and 23, 2019 to discuss current research progress and future collaborative efforts.

Matching funds drive for immune dysregulation in ME/CFS

A generous donor has offered to match up to $25,000 in donations to the Cornell Center for Enervating Neuroimmune Disease for our work on immune dysregulation in ME/CFS, which was recently described in Dr. Maureen Hanson’s talk at the Stanford OMF Community Symposium.

Please visit our donation page if you wish to support our work on the immune system in ME/CFS.  All donations are gratefully received.

Third annual OMF community symposium

Dr. Maureen Hanson

The Third Annual Community Symposium on the Molecular Basis of ME/CFS followed the Open Medicine Foundation working group meeting at Stanford University on September 7th, 2019. Keynote speaker, Dr. Maureen Hanson, started her talk discussing data on metabolomics, immune cells, extracellular vesicles, and RNA gene expression. The second portion of her talk went into her thoughts on the disease. OMF has uploaded her talk to YouTube, which can be found here.

Third annual OMF working group meeting

The Open Medicine Foundation held their third annual collaborative team meeting on ME/CFS. Dr. Maureen Hanson joined approximately 60 other researchers at Standford University from September 4th to 6th, 2019 to discuss their latest unpublished and preliminary data on the disease. A diverse field of scientific topics were discussed as noted in the agenda.

Collaborators publish CPET case report

Our collaborators at the Workwell Foundation, working with physical therapists and exercise physiologists, have published a case report in the Cardiopulmonary Physical Therapy Journal on measurement reproducibility over the two days of a two-day cardiopulmonary exercise test (CPET). The report looked at the variability of CPET results from six people with and without medical diagnoses of fatiguing illnesses. All of the participants were women and matched by age and BMI. Although the authors point out that generalizations are not possible due to the low number of included subjects, the response to exercise by both individuals with ME/CFS is important to highlight. 

Continue reading “Collaborators publish CPET case report”

Recruitment update at Los Angeles site

CPET demonstration

Now recruiting in the Los Angeles area:  People with ME/CFS and healthy, inactive control participants for the NIH-funded Cornell University Collaborative Research Center study of ME/CFS.  If accepted into the study, participants will complete two cardiopulmonary exercise tests over two days with blood drawn before and after each test, and wear a wrist watch device to measure physical activity for 10 days before and 10 days after the exercise tests.  Exercise testing will be completed at the ID Med clinic in Torrance, CA.  For more information and/or to be screened for acceptance into the study, please contact:

Jared Stevens
jared@workwellfoundation.org
209-599-7194

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