Cellular Metabolism of Immune Cells

Alexandra Mandarano

At the NIH Accelerating Research on ME/CFS meeting, Alexandra Mandarano, a Ph.D. candidate in Dr. Hanson’s lab, presented “Cellular Metabolism of Immune Cells”. The talk outlines a study that was performed in collaboration with Simmaron Research and focused on immunometabolism in people with ME/CFS as well as in healthy controls. To elaborate further, Alexandra Mandarano with the help of Jessica Maya, a graduate student in Dr. Hanson’s lab, performed Seahorse bioenergetics assays along with other experiments to better understand the metabolic fitness of immune cells from this population. Please see the video below to watch the full talk.

Mitochondrial DNA Mutation and Disease

Zhenglong Gu, Ph.D.

Center member Zhenglong Gu, PhD, presented on mitochondrial DNA mutation and disease at Cornell University on April 19, 2019. Dr. Gu is participating in the ENID Center to examine the role of mitochondrial genomes in ME/CFS.

“Next Steps for ME/CFS Research”

Dr. Maureen Hanson

Dr. Maureen Hanson spoke on the “Next Steps for ME/CFS Research” panel at the NIH meeting “Accelerating Research on ME/CFS” on April 5, 2019.  The text of her statement and some by Dr. Jose Montoya on the same panel can be found here.  A transcript of the prior remarks at the meeting by Dr. Francis Collins is available here.

Review Concerning Chronotropic Intolerence in ME/CFS

Our collaborators at Workwell Foundation have published a review concerning chronotropic incompetence in ME/CFS patients. What this means is that studies that have ME/CFS subjects exercise to a percentage of their maximal heart rate may be actually having the subject exercise at their maximum capacity, since their actual heart rate may often be lower than expected. Please see the link below to be directed to the publication.

https://www.frontiersin.org/articles/10.3389/fped.2019.00082

Outreach in Japan

Image Credit: admissions.oist.jp

This past November, @DrMaureenHanson visited the Okinawa Institute of Science and Technology Graduate University in Japan to participate in their distinguished speaker series. Dr. Hanson’s talk provided general awareness about ME/CFS and shared details on the Center’s research. In particular, the research topics covered were the functioning of immune cells, cellular metabolism, the microbiome, neuroimaging, and exercise physiology.  While in Japan, Dr. Hanson spoke with a representative of the Japan ME Association.  ME/CFS researchers in Japan hope to attend the April 2019 NIH meeting.

New Center Manager

Let us welcome Carl Franconi to the Cornell ME/CFS Collaborative Research Center team. He will be joining us as the Manager for the Center for Enervating NeuroImmune Disease. Carl will be taking over the administrative workload from Ms. Susi Varvayanis, who has recently taken a full-time position in the Graduate School to pursue her interest in supporting PhDs interested in non-academic careers, a role she had been carrying out part-time while efficiently managing our NIH ME/CFS CRC.

Continue reading “New Center Manager”

New metabolomics study published in Metabolites

Arnaud Germain, Ph.D.

The Hanson lab, which is a member of our Center, has recently published a metabolomics study in the journal Metabolites. Visit https://www.facebook.com/CornellMECFSCenter/ for a summary of the article. The complete publication can be accessed using the link below.

https://www.mdpi.com/2218-1989/8/4/90/htm

Arnaud Germain, David Ruppert, Susan M. Levine, and Maureen R. Hanson. 2018.  Prospective Biomarkers from Plasma Metabolomics of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome Implicate Redox Imbalance in Disease Symptomatology. Metabolites 8(4), 90

New York City ME/CFS recruitment has begun

The Weill Cornell Medical Center is recruiting individuals between the ages of 21-65 whose doctor has found no cause for their severe fatigue. Please contact Xiangling Mao by phone at (212) 746-2632 or email at xim2004@med.cornell.edu for more information about the study and to determine if you are eligible.

Study participation includes a visit to the study physician’s office to fill out a questionnaire on physical and mental health, and a medical examination. If deemed eligible, a visit to Weill Cornell Medicine includes a questionnaire, magnetic brain imaging (MRI), blood draws, urine tests, a cardiopulmonary exercise test (CPET) and positron emission tomography scan (PET). Participants will be compensated for their time.

Please see the NYC -Recruitment-Flyer for additional details, and share it with others who are able to travel to the site if they are deemed eligible.

Community symposium

OMF logoThe second annual Community Symposium on the Molecular Basis of ME/CFS will be held at Stanford University on September 29, 2018.  Maureen Hanson is among the distinguished list of speakers.

Sponsored by Open Medicine Foundation (OMF)
WHEN: Saturday, September 29, 2018
WHERE: Paul Brest Hall, Stanford University, Palo Alto, CA

Full details about the symposium can be found here.

UPDATE: Maureen’s complete talk was recorded and can be viewed here.

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