NIH ME/CFS Collaborative Research Center 2023-2028 (U54AI178855) Participant Interactions Opportunities to volunteer for studies. Muscle Tissue Sections of muscle from ME/CFS and control subjects. Immune Cell Dysfunction Classical monocyte and platelet function. Cell-free RNA Plasma RNA content before and after exercise. Extracellular Vesicle Cargo Protein and RNA cargo of vesicles from different tissues. Multiomics Comparison of multiple types of data.