NIH ME/CFS Collaborative Research Center 2023-2028 (U54AI178855) Participant Interactions Opportunities to volunteer for studies. Muscle Tissue Sections of muscle from ME/CFS and control subjects. Immune Cell Dysfunction Classical monocyte and platelet function. Cell-free RNA Plasma RNA content before and after exercise. Extracellular Vesicle Cargo Protein and RNA cargo of vesicles from different tissues. Endothelial Function Endothelium in vivo and in vitro and hemostasis. Multiomics Comparison of multiple types of data.