Published on August 12, 2021, Maureen Hanson wrote an editorial in Frontiers Science News that highlights the enterovirus theory of ME/CFS. Particularly, Hanson emphasizes that, “ME/CFS is neither a rare nor a trivial illness.” She provides insight into the potential link between ME/CFS and a chronic EV infection. This probable link was reviewed in detail in a Frontiers in Medicine June 2021 article by Adam O’Neal and Hanson. Hanson discusses the possibility that SARS viruses may be the second class of RNA viruses to cause a chronic illness, given the existence of “long COVID.”
For International ME/CFS Awareness Day, we would like to announce the official publication of a large metabolomics study from our Center. The work led by Arnaud Germain, PhD, describes results from a longitudinal plasma metabolite study associated with a 2-day cardiopulmonary exercise test (CPET). Over 100 individuals, including both females and males, were assayed before and after both days of the 2-day CPET. The article is open access in the journal JCI Insight. The quote below, from this publication, does an excellent job at summarizing the study.
Our longitudinal study design has allowed us to identify a number of pathways that diverge between healthy individuals and those with ME/CFS 24 hours after an exercise challenge, at which time patients typically experience PEM. Inability to recover properly after exertion is one of the most disabling symptoms of ME/CFS. Our study provides insight into the metabolic changes that are inimical to proper response to physical effort.
Back in January 2020, Germain et al published a metabolomics paper in Metabolites stating:
The latest worldwide prevalence rate projects that over 65 million patients suffer from myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)…
This 65 million people with ME/CFS figure has brought about some attention resulting in this letter to the Editor. Importantly, this letter brings several more supporting references beyond the initial Valdez et al publication. The key takeaway from the letter is that the prevalence of ME/CFS is likely much greater than the oft-cited figure of “20 million worldwide.”
Hanson Lab alumna, Alexandra Mandarano ’19 Ph.D., received the Laboratory Product Sales (LPS) award for her December 2019 JCI publication. The LPS award is granted to a student of the graduate field Genomics, Genomics and Development who is first author on what is judged to be the “best” student paper published in a calendar year. The award includes Mandarano’s name engraved on a plaque in the Department of Molecular Biology and Genetics office. Congratulations, Dr. Mandarano!
Center investigator Dr. Ludovic Giloteaux is lead author of a new publication out in the Journal of Translational Medicine. The paper describes cytokine profiling in extracellular vesicles (EVs) in ME/CFS. The study specifically looks at EVs from the plasma of 70 participants, 35 of which are diagnosed with ME/CFS and compared with 35 healthy controls. Both female and male participants were included in this work. Dr. Jesus Castro-Marrero visited our lab from Spain on a fellowship to contribute to the project.
One key finding of the study is the noted disturbances in cytokine networks.. Disturbances in these cytokine networks were seen in both plasma and EVs, and provides further evidence of immune dysregulation in ME/CFS. We are using information from this work to inform our further studies on EVs from blood collected before and after an exercise challenge. Stay tuned for future publications from our Center on this topic.
We are proud to announce our latest plasma proteomics publication is available as open access in Proteomes.
This manuscript takes a look at 4,790 circulating plasma proteins from 20 ME/CFS women compared to 20 healthy women, over an unprecedented range, for ME/CFS, of 9 orders of magnitude.
Pathway analysis uncovered disrupted cell-to-cell communication, specifically in the ephrin-Eph signaling pathway. This pathway is crucial for many aspects of our body’s homeostasis, including development, physiology, and disease regulation.
Additionally, the paper outlines promising results for the development of a diagnostic test using protein ratios.
First author, Arnaud Germain, PhD, outlines these findings in a video abstract below.
Chinese, French, and Spanish subtitles for the video abstract are available. See video settings to select an option.
This methodologically focused review covers aspects of ME/CFS pathophysiology that are consistent with chronic enterovirus infection outcomes and then closely examines the technology used in in past ME/CFS publications to determine how rigorously the enterovirus theory of disease etiology has been investigated.
Dr. Arnaud Germain, a member of the Hanson Lab, is the lead author on a new publication in the journal Metabolites. The paper describes a metabolomics study on the plasma of 52 female subjects. A large emphasis on lipids was observed in the approximately 1,750 blood compound datapoints. As summarized in the illustration below, notable changes were uncovered when comparing the ME/CFS and control cohorts.
The ENID Center is excited to announce a new publication in the Journal of Clinical Investigation. Recent Hanson Lab graduate, Dr. Alexandra Mandarano, is the lead author of “Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations”. This paper goes into our research exploring the immune system in people with ME/CFS.
UPDATE: The final publication of the paper was released on February 10, 2020. Accompanying this release, Dr. Mady Hornig wrote a related commentary: “Can the light of immunometabolism cut through “brain fog”?“.
Dr. Daniel Peterson and Simmaron Research staff Dr. Gunnar Gottschalk and Marco Maynard provided blood samples from carefully diagnosed ME/CFS cases and controls that were critical for carrying out the study. Thanks to Simmaron Research and a private donor, as well as NIH, for financial support for the study. A press release was issued by NIH.
Furthermore, we have launched a new initiative to help expand the reach of our research. Dr. Mandarano has recorded a talk that walks you through this publication. The video is hosted on our new YouTube channel. Check out this video below and stay tuned for future posts and videos about our research.
Our collaborators at the Workwell Foundation, working with physical therapists and exercise physiologists, have published a case report in the Cardiopulmonary Physical Therapy Journal on measurement reproducibility over the two days of a two-day cardiopulmonary exercise test (CPET). The report looked at the variability of CPET results from six people with and without medical diagnoses of fatiguing illnesses. All of the participants were women and matched by age and BMI. Although the authors point out that generalizations are not possible due to the low number of included subjects, the response to exercise by both individuals with ME/CFS is important to highlight.Continue reading “Collaborators publish CPET case report”