Collaborators publish CPET case report

Our collaborators at the Workwell Foundation, working with physical therapists and exercise physiologists, have published a case report in the Cardiopulmonary Physical Therapy Journal on measurement reproducibility over the two days of a two-day cardiopulmonary exercise test (CPET). The report looked at the variability of CPET results from six people with and without medical diagnoses of fatiguing illnesses. All of the participants were women and matched by age and BMI. Although the authors point out that generalizations are not possible due to the low number of included subjects, the response to exercise by both individuals with ME/CFS is important to highlight. 

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Gut microbiome publication

On January 22, 2018, PeerJ published “Eukaryotes in the gut microbiota in myalgic encephalomyelitis/chronic fatigue syndrome”. The publication is work done by Center participants regarding the diversity of eukaryotes in the gut microbiomes of people with ME/CFS and in healthy controls.

A recent research highlight by the Solve ME/CFS Initiative provides a detailed summary of this article. SMCI’s research summary can be viewed here.


Figure 1: Individual relative taxa abundances in healthy controls and ME/CFS patients. (from publication)

Mandarano AH, Giloteaux L, Keller BA, Levine SM, Hanson MR. 2018. Eukaryotes in the gut microbiota in myalgic encephalomyelitis/chronic fatigue syndrome. PeerJ 6:e4282 https://doi.org/10.7717/peerj.4282

Review concerning chronotropic intolerance in ME/CFS

Our collaborators at Workwell Foundation have published a review concerning chronotropic incompetence in ME/CFS patients. What this means is that studies that have ME/CFS subjects exercise to a percentage of their maximal heart rate may be actually having the subject exercise at their maximum capacity, since their actual heart rate may often be lower than expected. Please see the link below to be directed to the publication.

https://www.frontiersin.org/articles/10.3389/fped.2019.00082

New metabolomics study published in Metabolites

Arnaud Germain, Ph.D.

The Hanson lab, which is a member of our Center, has recently published a metabolomics study in the journal Metabolites. Visit https://www.facebook.com/CornellMECFSCenter/ for a summary of the article. The complete publication can be accessed using the link below.

https://www.mdpi.com/2218-1989/8/4/90/htm

Arnaud Germain, David Ruppert, Susan M. Levine, and Maureen R. Hanson. 2018.  Prospective Biomarkers from Plasma Metabolomics of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome Implicate Redox Imbalance in Disease Symptomatology. Metabolites 8(4), 90

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