NYSDOH Panel Session on ME/CFS in Age of COVID-19

Center Director Dr. Maureen Hanson will be presenting current scientific research on ME/CFS during a panel session hosted by New York State Department of Health (NYS DOH). The session titled “Scientific Research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in the Age of COVID-19” will be moderated by Dr. Charles Gonzalez. Dr. Ian Lipkin (Columbia University) and Dr. Avindra Nath (NIH) will be joining Hanson as panel presenters.

UPDATE: In case you missed the panel discussion, NYS DOH released a recording along with each presenter’s slides. Direct links to the recording and Dr. Hanson’s slides are below. Visit the NYS DOH ME/CFS website for more information.

Altered T cell metabolism and dysregulated cytokine associations in ME/CFS

The ENID Center is excited to announce a new publication in the Journal of Clinical Investigation. Recent Hanson Lab graduate, Dr. Alexandra Mandarano, is the lead author of “Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations”. This paper goes into our research exploring the immune system in people with ME/CFS.

UPDATE: The final publication of the paper was released on February 10, 2020. Accompanying this release, Dr. Mady Hornig wrote a related commentary: “Can the light of immunometabolism cut through “brain fog”?“.

Dr. Daniel Peterson and Simmaron Research staff Dr. Gunnar Gottschalk and Marco Maynard provided blood samples from carefully diagnosed ME/CFS cases and controls that were critical for carrying out the study.  Thanks to Simmaron Research and a private donor, as well as NIH, for financial support for the study.  A press release was issued by NIH.

Furthermore, we have launched a new initiative to help expand the reach of our research. Dr. Mandarano has recorded a talk that walks you through this publication. The video is hosted on our new YouTube channel. Check out this video below and stay tuned for future posts and videos about our research.

Betsy Keller speaks in Norway November 2019

As part of the Norwegian ME Association’s Knowledge Campaign 2019, Dr. Betsy Keller traveled to Norway to present on post-exertional malaise. The Norwegian ME Association has uploaded her talk to YouTube and can be watched using the embedded video below. Additionally, the following links will direct you to associated information translated to English via Google Translate.

Norwegian ME Association’s Knowledge Campaign 2019

Post about Dr. Keller’s talk including information on PEM management

 

Third annual OMF community symposium

Dr. Maureen Hanson

The Third Annual Community Symposium on the Molecular Basis of ME/CFS followed the Open Medicine Foundation working group meeting at Stanford University on September 7th, 2019. Keynote speaker, Dr. Maureen Hanson, started her talk discussing data on metabolomics, immune cells, extracellular vesicles, and RNA gene expression. The second portion of her talk went into her thoughts on the disease. OMF has uploaded her talk to YouTube, which can be found here.

Inaugural Harvard ME/CFS collaboration symposium

Symposium participants

Dr. Maureen Hanson participated in the inaugural Harvard ME/CFS Collaboration 2019 Scientific and Public Symposium sponsored by the Open Medicine Foundation that was held in Boston, MA on June 6-7, 2019. On June 6 she presented a talk on ongoing research in the NIH-funded Cornell ME/CFS U54 Center. She also presented on June 7 at the public symposium held in a theater in nearby Somerville, MA. The talks from the public symposium have been made available by OMF. Dr. Hanson’s talk is below and the full list of talks can be found here.

Immune dysregulation in ME/CFS

InvestinME Research Events

Richard Simpson, event organizing, from InvestinME

InvestinME Research hosted a series of events in London with the purpose of promoting better education about ME/CFS and increasing international collaboration on ME/CFS research. The series began with the Thinking the Future Young/ECR conference on May 28th, 2019, for which Hanson lab graduate student Alexandra Mandarano received a travel scholarship to attend. Dr. Maureen Hanson attended and presented at the ninth Biomedical Research into ME Colloquium and at the public 14th Invest in ME Research Conference on May 31st.

UPDATE: Presentations and the conference report from the 14th Invest in ME Research International ME Conference are now available. Dr. Maureen Hanson‘s talk is among those uploaded and is included below. The full report is available on the InvestinME website here.

Exertion intolerance: What is the evidence telling us?

Betsy Keller, Ph.D.

Clinical core co-director Dr. Betsy Keller presented on the second day of the NIH Accelerating Research on ME/CFS meeting. Dr. Keller outlined exertion intolerance in ME/CFS drawing upon her years of experience in the field. Her talk includes some preliminary data being generated from our NIH-funded Center. Dr. Keller’s complete talk can be viewed below.

Cellular Metabolism of Immune Cells

Alexandra Mandarano

At the NIH Accelerating Research on ME/CFS meeting, Alexandra Mandarano, a Ph.D. candidate in Dr. Hanson’s lab, presented “Cellular Metabolism of Immune Cells”. The talk outlines a study that was performed in collaboration with Simmaron Research and focused on immunometabolism in people with ME/CFS as well as in healthy controls. To elaborate further, Alexandra Mandarano with the help of Jessica Maya, a graduate student in Dr. Hanson’s lab, performed Seahorse bioenergetics assays along with other experiments to better understand the metabolic fitness of immune cells from this population. Please see the video below to watch the full talk.

“Next Steps for ME/CFS Research”

Dr. Maureen Hanson

Dr. Maureen Hanson spoke on the “Next Steps for ME/CFS Research” panel at the NIH meeting “Accelerating Research on ME/CFS” on April 5, 2019.  The text of her statement and some by Dr. Jose Montoya on the same panel can be found here.  A transcript of the prior remarks at the meeting by Dr. Francis Collins is available here.

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