Explore peer-reviewed publications from Cornell Center researchers and collaborators advancing the understanding of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

Spatial transcriptomics maps host-gut microbiome biogeography at high resolution. Ntekas I, Takayasu L, McKellar DW, Grodner B, Holdener C, Schweitzer P, Park YS, Sauthoff M, Shi Q, Brito IL, De Vlaminck I. Nat Microbiol. 2026 May;11(5):1193-1204. doi: 10.1038/s41564-026-02286-7. Epub 2026 Mar 6. PMID: 41792309; PMCID: PMC13171632.

Temporal Dynamics of the Plasma Proteomic Landscape Reveals Maladaptation in ME/CFS Following Exertion. Mol Cell Proteomics. Germain A, Glass KA, Eckert MA, Giloteaux L, Hanson MR. 2025 Dec;24(12):101467. doi: 10.1016/j.mcpro.2025.101467. Epub 2025 Nov 17. PMID: 41237904; PMCID: PMC12757482.

Circulating cell-free RNA signatures for the characterization and diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome. Gardella AE, Eweis-LaBolle D, Loy CJ, Belcher ED, Lenz JS, Franconi CJ, Scofield SY, Grimson A, Hanson MR, De Vlaminck I. Proc Natl Acad Sci U S A. 2025 Aug 19;122(33):e2507345122. doi: 10.1073/pnas.2507345122. Epub 2025 Aug 11. PMID: 40789036; PMCID: PMC12377778.

Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome. Glass KA, Giloteaux L, Zhang S, Hanson MR. Clin Transl Med. 2025 May;15(5):e70346. doi: 10.1002/ctm2.70346. PMID: 40465195; PMCID: PMC12135887.

An In-Depth Exploration of the Autoantibody Immune Profile in ME/CFS Using Novel Antigen Profiling Techniques. Germain A, Jaycox JR, Emig CJ, Ring AM, Hanson MR. Int J Mol Sci. 2025 Mar 20;26(6):2799. doi: 10.3390/ijms26062799. PMID: 40141440; PMCID: PMC11943395.

Transcriptional reprogramming primes CD8+ T cells toward exhaustion in Myalgic encephalomyelitis/chronic fatigue syndrome. Iu DS, Maya J, Vu LT, Fogarty EA, McNairn AJ, Ahmed F, Franconi CJ, Munn PR, Grenier JK, Hanson MR, Grimson A. Proc Natl Acad Sci U S A. 2024 Dec 10;121(50):e2415119121. doi: 10.1073/pnas.2415119121. Epub 2024 Dec 2. PMID: 39621903; PMCID: PMC11648872.

Infection-associated chronic conditions: Why Long Covid is our best chance to untangle Osler’s web. Peluso MJ, Hanson MR, Deeks SG. Sci Transl Med. 2024 Nov 13;16(773):eado2101. doi: 10.1126/scitranslmed.ado2101. Epub 2024 Nov 13. PMID: 39536121; PMCID: PMC12919982.

Cardiopulmonary and metabolic responses during a 2-day CPET in myalgic encephalomyelitis/chronic fatigue syndrome: translating reduced oxygen consumption to impairment status to treatment considerations. Keller B, Receno CN, Franconi CJ, Harenberg S, Stevens J, Mao X, Stevens SR, Moore G, Levine S, Chia J, Shungu D, Hanson MR. J Transl Med. 2024 Jul 5;22(1):627. doi: 10.1186/s12967-024-05410-5. PMID: 38965566; PMCID: PMC11229500.

Dysregulation of extracellular vesicle protein cargo in female myalgic encephalomyelitis/chronic fatigue syndrome cases and sedentary controls in response to maximal exercise. Giloteaux L, Glass KA, Germain A, Franconi CJ, Zhang S, Hanson MR. J Extracell Vesicles. 2024 Jan;13(1):e12403. doi: 10.1002/jev2.12403. PMID: 38173127; PMCID: PMC10764978.

Single-cell transcriptomics of the immune system in ME/CFS at baseline and following symptom provocation. Vu LT, Ahmed F, Zhu H, Iu DSH, Fogarty EA, Kwak Y, Chen W, Franconi CJ, Munn PR, Tate AE, Levine SM, Stevens J, Mao X, Shungu DC, Moore GE, Keller BA, Hanson MR, Grenier JK, Grimson A. Cell Rep Med. 2024 Jan 16;5(1):101373. doi: 10.1016/j.xcrm.2023.101373. PMID: 38232699; PMCID: PMC10829790.

The viral origin of myalgic encephalomyelitis/chronic fatigue syndrome. Hanson MR. PLoS Pathog. 2023 Aug 17;19(8):e1011523. doi: 10.1371/journal.ppat.1011523. PMID: 37590180; PMCID: PMC10434940.

Proteomics and cytokine analyses distinguish myalgic encephalomyelitis/chronic fatigue syndrome cases from controls. Giloteaux L, Li J, Hornig M, Lipkin WI, Ruppert D, Hanson MR. J Transl Med. 2023 May 13;21(1):322. doi: 10.1186/s12967-023-04179-3. PMID: 37179299; PMCID: PMC10182359.

Recovery from Exercise in Persons with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Moore GE, Keller BA, Stevens J, Mao X, Stevens SR, Chia JK, Levine SM, Franconi CJ, Hanson MR. Medicina (Kaunas). 2023 Mar 15;59(3):571. doi: 10.3390/medicina59030571. PMID: 36984572; PMCID: PMC10059925.

Urine Metabolomics Exposes Anomalous Recovery after Maximal Exertion in Female ME/CFS Patients. Glass KA, Germain A, Huang YV, Hanson MR. Int J Mol Sci. 2023 Feb 12;24(4):3685. doi: 10.3390/ijms24043685. PMID: 36835097; PMCID: PMC9958671.

Altered Fatty Acid Oxidation in Lymphocyte Populations of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Maya J, Leddy SM, Gottschalk CG, Peterson DL, Hanson MR. Int J Mol Sci. 2023 Jan 19;24(3):2010. doi: 10.3390/ijms24032010. PMID: 36768336; PMCID: PMC9916395.

Survey of Anti-Pathogen Antibody Levels in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. O’Neal AJ, Glass KA, Emig CJ, Vitug AA, Henry SJ, Shungu DC, Mao X, Levine SM, Hanson MR. Proteomes. 2022 Jun 13;10(2):21. doi: 10.3390/proteomes10020021. PMID: 35736801; PMCID: PMC9228258.

Plasma metabolomics reveals disrupted response and recovery following maximal exercise in myalgic encephalomyelitis/chronic fatigue syndrome. Germain A, Giloteaux L, Moore GE, Levine SM, Chia JK, Keller BA, Stevens J, Franconi CJ, Mao X, Shungu DC, Grimson A, Hanson MR. JCI Insight. 2022 May 9;7(9):e157621. doi: 10.1172/jci.insight.157621. PMID: 35358096; PMCID: PMC9090259.

The Enterovirus Theory of Disease Etiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Critical Review. O’Neal AJ, Hanson MR. Front Med (Lausanne). 2021 Jun 18;8:688486. doi: 10.3389/fmed.2021.688486. PMID: 34222292; PMCID: PMC8253308.

In-Depth Analysis of the Plasma Proteome in ME/CFS Exposes Disrupted Ephrin-Eph and Immune System Signaling. Germain A, Levine SM, Hanson MR. Proteomes. 2021 Jan 29;9(1):6. doi: 10.3390/proteomes9010006. PMID: 33572894; PMCID: PMC7931008.

Cytokine profiling of extracellular vesicles isolated from plasma in myalgic encephalomyelitis/chronic fatigue syndrome: a pilot study. Giloteaux L, O’Neal A, Castro-Marrero J, Levine SM, Hanson MR. J Transl Med. 2020 Oct 12;18(1):387. doi: 10.1186/s12967-020-02560-0. PMID: 33046133; PMCID: PMC7552484.

Letter to the Editor of Metabolites. Hanson MR, Germain A. Metabolites. 2020 May 25;10(5):216. doi: 10.3390/metabo10050216. PMID: 32466160; PMCID: PMC7281557.

Comprehensive Circulatory Metabolomics in ME/CFS Reveals Disrupted Metabolism of Acyl Lipids and Steroids. Germain A, Barupal DK, Levine SM, Hanson MR. Metabolites. 2020 Jan 14;10(1):34. doi: 10.3390/metabo10010034. PMID: 31947545; PMCID: PMC7023305.

Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations. Mandarano AH, Maya J, Giloteaux L, Peterson DL, Maynard M, Gottschalk CG, Hanson MR. J Clin Invest. 2020 Mar 2;130(3):1491-1505. doi: 10.1172/JCI132185. PMID: 31830003; PMCID: PMC7269566.

Prospective Biomarkers from Plasma Metabolomics of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Implicate Redox Imbalance in Disease Symptomatology. Germain A, Ruppert D, Levine SM, Hanson MR. Metabolites. 2018 Dec 6;8(4):90. doi: 10.3390/metabo8040090. PMID: 30563204; PMCID: PMC6315598.

Eukaryotes in the gut microbiota in myalgic encephalomyelitis/chronic fatigue syndrome. Mandarano AH, Giloteaux L, Keller BA, Levine SM, Hanson MR. PeerJ. 2018 Jan 22;6:e4282. doi: 10.7717/peerj.4282. PMID: 29375937; PMCID: PMC5784577.

The gut microbiome in Myalgic Encephalomyelitis. Hanson MR, Giloteaux L. Biochemist. 2017 Apr;39(2):10-13.

A Pair of Identical Twins Discordant for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Differ in Physiological Parameters and Gut Microbiome Composition. Giloteaux L, Hanson MR, Keller BA. Am J Case Rep. 2016 Oct 10;17:720-729. doi: 10.12659/ajcr.900314. PMID: 27721367; PMCID: PMC5058431.

Reduced diversity and altered composition of the gut microbiome in individuals with myalgic encephalomyelitis/chronic fatigue syndrome. Giloteaux L, Goodrich JK, Walters WA, Levine SM, Ley RE, Hanson MR. Microbiome. 2016 Jun 23;4(1):30. doi: 10.1186/s40168-016-0171-4. PMID: 27338587; PMCID: PMC4918027.

Inability of myalgic encephalomyelitis/chronic fatigue syndrome patients to reproduce VO₂peak indicates functional impairment. Keller BA, Pryor JL, Giloteaux L.J Transl Med. 2014 Apr 23;12:104. doi: 10.1186/1479-5876-12-104. PMID: 24755065; PMCID: PMC4004422.